It is now clear that the Sec61 complex does not have a monopoly on co-translational insertion, with some transmembrane proteins preferentially utilising the ER membrane complex instead. We propose that the Sec61 complex acts as a dynamic hub for co-translational protein translocation at the ER, proactively recruiting a range of accessory complexes that enhance and regulate its function in response to different protein clients. Over thirty years after its initial discovery, we now understand that the Sec61 complex is in fact the central piece of an elaborate jigsaw puzzle, which can be partly solved using new research findings. Whilst Sec61-mediated protein translocation is typically coupled to polypeptide synthesis, suggestive of significant complexity, an obvious characteristic of this core translocation machinery is its surprising simplicity. Thus, combined with the GRS, this will be a great opportunity for early career researchers to present their work.The Sec61 complex is the major protein translocation channel of the endoplasmic reticulum (ER), where it plays a central role in the biogenesis of membrane and secretory proteins. Many talks at the GRC will be selected from abstracts. It is also the first time the GRC will be accompanied by a GRS. This is first time the membrane protein folding GRC will be held in Europe, following 3 successful meetings in the US. Topics will additionally focus on new methods to prepare and probe samples of increasing complexity ranging from artificial, in vitro systems to more intricate cellular preparations. The role of lipids in folding, regulation and membrane organization will also be discussed. Sessions will address recent progress in developing and tailoring state-of-the-art measurement techniques and computational approaches to elucidate molecular mechanisms. The GRC will explore new tools that can be applied to the challenging problem of membrane protein folding, with an emphasis on connecting fundamental parameters obtained on model systems to cellular consequences. #Membrane pro seriesThe latest meeting is the 4th in the series and cultivates the combination of cutting-edge biophysics, biochemistry and cell biology established in the initial conferences. This relatively new conference series brings together researchers tackling this frontier of membrane protein folding. The pivotal class of membrane proteins has been avoided as they are notoriously difficult to study. The majority of folding research has focused on a subset of the proteome experimentally-amenable, water-soluble proteins. Protein function is governed by the 3D fold, with health depending on the success of folding and disease on its failure. This conference showcases advances in the evolving field of membrane protein folding.Ĭorrectly folded proteins are essential for life. #Membrane pro freeIn addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The Membrane Protein Folding GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages.
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